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EDEM2 and OS-9 Are Required for ER-Associated Degradation of Non-Glycosylated Sonic Hedgehog

Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes. In S. cerevisiae, ER-resident lectins mediate substrate recognition through bipartite signals consisting of an unfolded local structure and the adjacent glycan. Trimming of the...

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Detalles Bibliográficos
Autores principales:	Tang, Hsiang-Yun, Huang, Chih-Hsiang, Zhuang, Ya-Han, Christianson, John C., Chen, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049591/ https://www.ncbi.nlm.nih.gov/pubmed/24910992 http://dx.doi.org/10.1371/journal.pone.0092164

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