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Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers

BACKGROUND: In several neurodegenerative diseases, hyperphosphorylation at position Ser129 is found in fibrillar deposits of alpha-synuclein (asyn), implying a pathophysiological role of asyn phosphorylation in neurodegeneration. However, recent animal models applying asyn phosphorylation mimics dem...

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Detalles Bibliográficos
Autores principales:	Nübling, Georg Sebastian, Levin, Johannes, Bader, Benedikt, Lorenzl, Stefan, Hillmer, Andreas, Högen, Tobias, Kamp, Frits, Giese, Armin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049638/ https://www.ncbi.nlm.nih.gov/pubmed/24911099 http://dx.doi.org/10.1371/journal.pone.0098906

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