Cargando…

Gastric cancer cell growth and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT

The Notch signaling pathway may be important in the development and progression of several malignancies. However, the functions of Notch signaling in epithelial-mesenchymal transition (EMT) remain largely unknown. The aim of the present study was to delineate Notch1 expression in gastric cancer (GC)...

Descripción completa

Detalles Bibliográficos
Autores principales:	LI, LU-CHUN, PENG, YANG, LIU, YAN-MIM, WANG, LU-LU, WU, XIAO-LING
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049710/ https://www.ncbi.nlm.nih.gov/pubmed/24932308 http://dx.doi.org/10.3892/ol.2014.1980

Ejemplares similares

Cervical Cancer Cell Growth, Drug Resistance, and Epithelial-Mesenchymal Transition Are Suppressed by γ-Secretase Inhibitor RO4929097
por: Wang, Lu, et al.
Publicado: (2018)

DAPT, a γ-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling
por: Feng, Jie, et al.
Publicado: (2019)

γ‐secretase inhibitor DAPT mitigates cisplatin‐induced acute kidney injury by suppressing Notch1 signaling
por: Soni, Hitesh, et al.
Publicado: (2018)

Effect of DAPT, a gamma secretase inhibitor, on tumor angiogenesis in control mice
por: Kalantari, Elmira, et al.
Publicado: (2013)

microRNA-503 inhibits gastric cancer cell growth and epithelial-to-mesenchymal transition
por: PENG, YANG, et al.
Publicado: (2014)

Confocal Raman Spectral Imaging Study of DAPT, a γ-secretase Inhibitor, Induced Physiological and Biochemical Reponses in Osteosarcoma Cells
por: Li, Jie, et al.
Publicado: (2020)

γ-secretase inhibitors, DAPT and RO4929097, promote the migration of Human Glioma Cells via Smad5-downregulated E-cadherin Expression
por: Chang, Shun-Fu, et al.
Publicado: (2021)

Epithelial Mesenchymal Transition and Pancreatic Tumor Initiating CD44+/EpCAM+ Cells Are Inhibited by γ-Secretase Inhibitor IX
por: Palagani, Vindhya, et al.
Publicado: (2012)

Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer
por: Su, Feng, et al.
Publicado: (2015)

The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition
por: Han, Jianxun, et al.
Publicado: (2009)

Effects of γ-secretase inhibitors in mouse colon
Publicado: (2012)

N-{N-[2-(3,5-Difluorophenyl)acetyl]-(S)-alanyl}-(S)-phenylglycine tert-butyl ester (DAPT): an inhibitor of γ-secretase, revealing fine electronic and hydrogen-bonding features
por: Czerwinski, Andrzej, et al.
Publicado: (2010)

Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase
por: Wang, Lie-Feng, et al.
Publicado: (2009)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
por: Sogorb-Esteve, Aitana, et al.
Publicado: (2017)

Contradictions between DAPT and PRECISE-DAPT scores with the severity of coronary lesion in acute coronary syndrome
por: Bi, Sisi, et al.
Publicado: (2020)

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats
por: Chen, Yixiong, et al.
Publicado: (2012)

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors
por: Ran, Yong, et al.
Publicado: (2015)

Correlations of DAPT score and PRECISE-DAPT score with the extent of coronary stenosis in acute coronary syndrome
por: Long, Tianyi, et al.
Publicado: (2018)

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
por: Ortega, Fernando, et al.
Publicado: (2013)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

More Insights on the Use of γ‐Secretase Inhibitors in Cancer Treatment
por: López‐Nieva, Pilar, et al.
Publicado: (2020)

A comparison of safety and efficacy between long-term DAPT and intensive statins combined with short-term DAPT for acute ischemic stroke
por: Deng, Ting, et al.
Publicado: (2023)

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP
por: Weissmiller, April M., et al.
Publicado: (2015)

γ-secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets
por: Dorneburg, Carmen, et al.
Publicado: (2016)

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
por: Funamoto, Satoru, et al.
Publicado: (2013)

Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition
por: Federman, Noah
Publicado: (2022)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

WTX inhibits gastric cancer migration through the reversal of epithelial-mesenchymal transition
por: Ye, Danli, et al.
Publicado: (2018)

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase
por: Lu, Xiaoli, et al.
Publicado: (2022)

The Cornelian dilemma(†) of quitting DAPT
por: Motovska, Zuzana, et al.
Publicado: (2021)

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
por: Mouchlis, Varnavas D., et al.
Publicado: (2020)

Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors
por: Arslanova, Dilyara, et al.
Publicado: (2010)

Notch versus the proteasome: what is the target of γ-secretase inhibitor-I?
por: Clementz, Anthony G, et al.
Publicado: (2009)

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation
por: Hajós, Mihály, et al.
Publicado: (2013)

γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
por: Ran, Yong, et al.
Publicado: (2017)

Evaluation of Virtual Screening Strategies for the Identification of γ-Secretase Inhibitors and Modulators
por: Ioppolo, Alicia, et al.
Publicado: (2021)

The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics
por: Song, Congkuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0ho8r6j1qakucbsqucago65od6