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Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction

The management of facial defects has rapidly changed in the last decade. Functional and esthetic requirements have steadily increased along with the refinements of surgery. In the case of advanced atrophy or jaw defects, extensive horizontal and vertical bone augmentation is often unavoidable to ena...

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Autores principales: Grimm, Wolf Dieter, Dannan, Aous, Giesenhagen, Bernd, Schau, Ingmar, Varga, Gabor, Vukovic, Mark Alexander, Sirak, Sergey Vladimirovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049728/
https://www.ncbi.nlm.nih.gov/pubmed/24921024
http://dx.doi.org/10.15283/ijsc.2014.7.1.23
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author Grimm, Wolf Dieter
Dannan, Aous
Giesenhagen, Bernd
Schau, Ingmar
Varga, Gabor
Vukovic, Mark Alexander
Sirak, Sergey Vladimirovich
author_facet Grimm, Wolf Dieter
Dannan, Aous
Giesenhagen, Bernd
Schau, Ingmar
Varga, Gabor
Vukovic, Mark Alexander
Sirak, Sergey Vladimirovich
author_sort Grimm, Wolf Dieter
collection PubMed
description The management of facial defects has rapidly changed in the last decade. Functional and esthetic requirements have steadily increased along with the refinements of surgery. In the case of advanced atrophy or jaw defects, extensive horizontal and vertical bone augmentation is often unavoidable to enable patients to be fitted with implants. Loss of vertical alveolar bone height is the most common cause for a non primary stability of dental implants in adults. At present, there is no ideal therapeutic approach to cure loss of vertical alveolar bone height and achieve optimal pre-implantological bone regeneration before dental implant placement. Recently, it has been found that specific populations of stem cells and/or progenitor cells could be isolated from different dental resources, namely the dental follicle, the dental pulp and the periodontal ligament. Our research group has cultured palatal-derived stem cells (paldSCs) as dentospheres and further differentiated into various cells of the neuronal and osteogenic lineage, thereby demonstrating their stem cell state. In this publication will be shown whether paldSCs could be differentiated into the osteogenic lineage and, if so, whether these cells are able to regenerate alveolar bone tissue in vivo in an athymic rat model. Furthermore, using these data we have started a proof of principle clinical- and histological controlled study using stem cell-rich palatal tissues for improving the vertical alveolar bone augmentation in critical size defects. The initial results of the study demonstrate the feasibility of using stem cell-mediated tissue engineering to treat alveolar bone defects in humans.
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spelling pubmed-40497282014-06-11 Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction Grimm, Wolf Dieter Dannan, Aous Giesenhagen, Bernd Schau, Ingmar Varga, Gabor Vukovic, Mark Alexander Sirak, Sergey Vladimirovich Int J Stem Cells Original Article The management of facial defects has rapidly changed in the last decade. Functional and esthetic requirements have steadily increased along with the refinements of surgery. In the case of advanced atrophy or jaw defects, extensive horizontal and vertical bone augmentation is often unavoidable to enable patients to be fitted with implants. Loss of vertical alveolar bone height is the most common cause for a non primary stability of dental implants in adults. At present, there is no ideal therapeutic approach to cure loss of vertical alveolar bone height and achieve optimal pre-implantological bone regeneration before dental implant placement. Recently, it has been found that specific populations of stem cells and/or progenitor cells could be isolated from different dental resources, namely the dental follicle, the dental pulp and the periodontal ligament. Our research group has cultured palatal-derived stem cells (paldSCs) as dentospheres and further differentiated into various cells of the neuronal and osteogenic lineage, thereby demonstrating their stem cell state. In this publication will be shown whether paldSCs could be differentiated into the osteogenic lineage and, if so, whether these cells are able to regenerate alveolar bone tissue in vivo in an athymic rat model. Furthermore, using these data we have started a proof of principle clinical- and histological controlled study using stem cell-rich palatal tissues for improving the vertical alveolar bone augmentation in critical size defects. The initial results of the study demonstrate the feasibility of using stem cell-mediated tissue engineering to treat alveolar bone defects in humans. Korean Society for Stem Cell Research 2014-05 /pmc/articles/PMC4049728/ /pubmed/24921024 http://dx.doi.org/10.15283/ijsc.2014.7.1.23 Text en Copyright ©2014, Korean Society for Stem Cell Research This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Grimm, Wolf Dieter
Dannan, Aous
Giesenhagen, Bernd
Schau, Ingmar
Varga, Gabor
Vukovic, Mark Alexander
Sirak, Sergey Vladimirovich
Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction
title Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction
title_full Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction
title_fullStr Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction
title_full_unstemmed Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction
title_short Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction
title_sort translational research: palatal-derived ecto-mesenchymal stem cells from human palate: a new hope for alveolar bone and cranio-facial bone reconstruction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049728/
https://www.ncbi.nlm.nih.gov/pubmed/24921024
http://dx.doi.org/10.15283/ijsc.2014.7.1.23
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