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Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers

The occurrence of severe neutropenia during treatment with irinotecan (CPT-11) is associated with the *6 and *28 alleles of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). However, the correlation between these variants and the occurrence of severe neutropenia in a low-dose CPT-11 regimen...

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Detalles Bibliográficos
Autores principales:	MORIYA, HIROYUKI, SAITO, KATSUHIKO, HELSBY, NUALA, SUGINO, SHIGEKAZU, YAMAKAGE, MICHIAKI, SAWAGUCHI, TAKERU, TAKASAKI, MASAHIKO, KATO, HIDENORI, KUROSAWA, NAHOKO
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049750/ https://www.ncbi.nlm.nih.gov/pubmed/24932285 http://dx.doi.org/10.3892/ol.2014.2046

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