DNA copy number alterations in pleomorphic leiomyosarcoma: A case report

Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alt...

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Autores principales: KANAMORI, MASAHIKO, YASUDA, TAKETOSHI, NOGAMI, SHIGEHARU, SUZUKI, KAYO, HORI, TAKESHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049769/
https://www.ncbi.nlm.nih.gov/pubmed/24932246
http://dx.doi.org/10.3892/ol.2014.2030
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author KANAMORI, MASAHIKO
YASUDA, TAKETOSHI
NOGAMI, SHIGEHARU
SUZUKI, KAYO
HORI, TAKESHI
author_facet KANAMORI, MASAHIKO
YASUDA, TAKETOSHI
NOGAMI, SHIGEHARU
SUZUKI, KAYO
HORI, TAKESHI
author_sort KANAMORI, MASAHIKO
collection PubMed
description Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12-13.1, 13q14.2-14.3, 15q25-26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (282M15/SP6) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data.
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spelling pubmed-40497692014-06-13 DNA copy number alterations in pleomorphic leiomyosarcoma: A case report KANAMORI, MASAHIKO YASUDA, TAKETOSHI NOGAMI, SHIGEHARU SUZUKI, KAYO HORI, TAKESHI Oncol Lett Articles Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12-13.1, 13q14.2-14.3, 15q25-26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (282M15/SP6) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data. D.A. Spandidos 2014-06 2014-04-03 /pmc/articles/PMC4049769/ /pubmed/24932246 http://dx.doi.org/10.3892/ol.2014.2030 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
KANAMORI, MASAHIKO
YASUDA, TAKETOSHI
NOGAMI, SHIGEHARU
SUZUKI, KAYO
HORI, TAKESHI
DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
title DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
title_full DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
title_fullStr DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
title_full_unstemmed DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
title_short DNA copy number alterations in pleomorphic leiomyosarcoma: A case report
title_sort dna copy number alterations in pleomorphic leiomyosarcoma: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049769/
https://www.ncbi.nlm.nih.gov/pubmed/24932246
http://dx.doi.org/10.3892/ol.2014.2030
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