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Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures

The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy for multiple sclerosis (MS), induces S1PR1 internalisation in T cells, subse...

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Detalles Bibliográficos
Autores principales:	Pritchard, Adam J., Mir, Anis K., Dev, Kumlesh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049809/ https://www.ncbi.nlm.nih.gov/pubmed/24911000 http://dx.doi.org/10.1371/journal.pone.0099444

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