The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate

Adult human pancreatic β-cells are primarily quiescent (G0) yet the mechanisms controlling their quiescence are poorly understood. Here, we demonstrate, by immunofluorescence and confocal microscopy, abundant levels of the critical negative cell cycle regulators, p27(Kip1) and p18(Ink4c), 2 key memb...

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Detalles Bibliográficos
Autores principales: Stein, Jeffrey, Milewski, Wieslawa M, Dey, Arunangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049839/
https://www.ncbi.nlm.nih.gov/pubmed/23896637
http://dx.doi.org/10.4161/isl.25605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049839/
https://www.ncbi.nlm.nih.gov/pubmed/23896637
http://dx.doi.org/10.4161/isl.25605

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