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Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis

The generation of neuronal cell diversity is controlled by interdependent mechanisms, including cell intrinsic programs and environmental cues. During development, the astonishing variety of neurons is originated according to a precise timetable that is managed by a complex network of genes specifyi...

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Detalles Bibliográficos
Autores principales: Kucherenko, Mariya M, Shcherbata, Halyna R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049850/
https://www.ncbi.nlm.nih.gov/pubmed/23839338
http://dx.doi.org/10.4161/fly.25241
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author Kucherenko, Mariya M
Shcherbata, Halyna R
author_facet Kucherenko, Mariya M
Shcherbata, Halyna R
author_sort Kucherenko, Mariya M
collection PubMed
description The generation of neuronal cell diversity is controlled by interdependent mechanisms, including cell intrinsic programs and environmental cues. During development, the astonishing variety of neurons is originated according to a precise timetable that is managed by a complex network of genes specifying individual types of neurons. Different neurons express specific sets of transcription factors, and they can be recognized by morphological characteristics and spatial localization, but, most importantly, they connect to each other and form functional units in a stereotyped fashion. This connectivity depends, mostly, on selective cell adhesion that is strictly regulated. While intrinsic factors specifying neuronal temporal identity have been extensively studied, an extrinsic temporal factor controlling neuronal temporal identity switch has not been shown. Our data demonstrate that pulses of steroid hormone act as a temporal cue to fine-tune neuronal cell differentiation. Here we also provide evidence that extrinsic JAK/STAT cytokine signaling acts as a spatial code in the process. Particularly, in Drosophila mushroom bodies, neuronal identity transition is controlled by steroid-dependent microRNAs that regulate spatially distributed cytokine-dependent signaling factors that in turn modulate cell adhesion. A new era of neuronal plasticity assessment via managing external temporal cues such as hormones and cytokines that specify individual types of neurons might open new possibilities for brain regenerative therapeutics.
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spelling pubmed-40498502014-06-12 Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis Kucherenko, Mariya M Shcherbata, Halyna R Fly (Austin) Extra View The generation of neuronal cell diversity is controlled by interdependent mechanisms, including cell intrinsic programs and environmental cues. During development, the astonishing variety of neurons is originated according to a precise timetable that is managed by a complex network of genes specifying individual types of neurons. Different neurons express specific sets of transcription factors, and they can be recognized by morphological characteristics and spatial localization, but, most importantly, they connect to each other and form functional units in a stereotyped fashion. This connectivity depends, mostly, on selective cell adhesion that is strictly regulated. While intrinsic factors specifying neuronal temporal identity have been extensively studied, an extrinsic temporal factor controlling neuronal temporal identity switch has not been shown. Our data demonstrate that pulses of steroid hormone act as a temporal cue to fine-tune neuronal cell differentiation. Here we also provide evidence that extrinsic JAK/STAT cytokine signaling acts as a spatial code in the process. Particularly, in Drosophila mushroom bodies, neuronal identity transition is controlled by steroid-dependent microRNAs that regulate spatially distributed cytokine-dependent signaling factors that in turn modulate cell adhesion. A new era of neuronal plasticity assessment via managing external temporal cues such as hormones and cytokines that specify individual types of neurons might open new possibilities for brain regenerative therapeutics. Landes Bioscience 2013-07-01 2013-07-09 /pmc/articles/PMC4049850/ /pubmed/23839338 http://dx.doi.org/10.4161/fly.25241 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Extra View
Kucherenko, Mariya M
Shcherbata, Halyna R
Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis
title Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis
title_full Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis
title_fullStr Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis
title_full_unstemmed Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis
title_short Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis
title_sort steroids as external temporal codes act via micrornas and cooperate with cytokines in differential neurogenesis
topic Extra View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049850/
https://www.ncbi.nlm.nih.gov/pubmed/23839338
http://dx.doi.org/10.4161/fly.25241
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