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Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome
BACKGROUND: Metabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase in carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before the clinical signs of cardiovascular disease appear. We aimed to investigate the prevalence of in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049947/ https://www.ncbi.nlm.nih.gov/pubmed/24869934 http://dx.doi.org/10.12659/MSM.889771 |
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author | Unal, Mustafa Aksoy, Duygu Yazgan Aydın, Yusuf Tanriover, Mine Durusu Berker, Dilek Karakaya, Jale Guler, Serdar |
author_facet | Unal, Mustafa Aksoy, Duygu Yazgan Aydın, Yusuf Tanriover, Mine Durusu Berker, Dilek Karakaya, Jale Guler, Serdar |
author_sort | Unal, Mustafa |
collection | PubMed |
description | BACKGROUND: Metabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase in carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before the clinical signs of cardiovascular disease appear. We aimed to investigate the prevalence of increased CIMT and ED as markers of atherosclerotic disease in patients with MS. MATERIAL/METHODS: Thirty-two patients with MS and 29 healthy controls were included. Anthropometric and biochemical parameters, along with total testosterone (TT), high sensitive C-reactive protein (hs-CRP), were recorded. Carotid artery intima-media thickness was measured. Erectile dysfunction was assessed with International Index of Erectile Function. RESULTS: Patients with MS had higher BMI, fasting plasma glucose, post-prandial plasma glucose, insulin, HOMA-IR, total cholesterol, triglycerides, hs-CRP, and CIMT, whereas TT levels were lower (p<0.0001). The prevalence and severity of erectile dysfunction were higher in patients with MS (p<0.0001). Erectile dysfunction scores correlated inversely with CIMT. MS patients with ED were older and had higher CIMT compared to those without ED. Increase in age and HOMA and decrease in TT increased the risk of ED. When KIMT exceeding the 95(th) percentile of healthy controls was accepted as a risk factor for CVD, presence of ED was the only determinant for this increase. CONCLUSIONS: Erectile dysfunction was more prevalent and severe in patients with MS and correlated with subclinical endothelial dysfunction. Total testosterone deficiency was prominent among MS patients. Presence of ED points to an increased risk of cardiovascular disease when MS is present. |
format | Online Article Text |
id | pubmed-4049947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40499472014-06-10 Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome Unal, Mustafa Aksoy, Duygu Yazgan Aydın, Yusuf Tanriover, Mine Durusu Berker, Dilek Karakaya, Jale Guler, Serdar Med Sci Monit Clinical Research BACKGROUND: Metabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase in carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before the clinical signs of cardiovascular disease appear. We aimed to investigate the prevalence of increased CIMT and ED as markers of atherosclerotic disease in patients with MS. MATERIAL/METHODS: Thirty-two patients with MS and 29 healthy controls were included. Anthropometric and biochemical parameters, along with total testosterone (TT), high sensitive C-reactive protein (hs-CRP), were recorded. Carotid artery intima-media thickness was measured. Erectile dysfunction was assessed with International Index of Erectile Function. RESULTS: Patients with MS had higher BMI, fasting plasma glucose, post-prandial plasma glucose, insulin, HOMA-IR, total cholesterol, triglycerides, hs-CRP, and CIMT, whereas TT levels were lower (p<0.0001). The prevalence and severity of erectile dysfunction were higher in patients with MS (p<0.0001). Erectile dysfunction scores correlated inversely with CIMT. MS patients with ED were older and had higher CIMT compared to those without ED. Increase in age and HOMA and decrease in TT increased the risk of ED. When KIMT exceeding the 95(th) percentile of healthy controls was accepted as a risk factor for CVD, presence of ED was the only determinant for this increase. CONCLUSIONS: Erectile dysfunction was more prevalent and severe in patients with MS and correlated with subclinical endothelial dysfunction. Total testosterone deficiency was prominent among MS patients. Presence of ED points to an increased risk of cardiovascular disease when MS is present. International Scientific Literature, Inc. 2014-05-29 /pmc/articles/PMC4049947/ /pubmed/24869934 http://dx.doi.org/10.12659/MSM.889771 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Unal, Mustafa Aksoy, Duygu Yazgan Aydın, Yusuf Tanriover, Mine Durusu Berker, Dilek Karakaya, Jale Guler, Serdar Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
title | Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
title_full | Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
title_fullStr | Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
title_full_unstemmed | Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
title_short | Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
title_sort | carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049947/ https://www.ncbi.nlm.nih.gov/pubmed/24869934 http://dx.doi.org/10.12659/MSM.889771 |
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