Partial inhibition of Cdk1 in G(2) phase overrides the SAC and decouples mitotic events

Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G(2) phase onwards. Addition of low doses of RO3306 in G(2) phase induced minor chro...

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Detalles Bibliográficos
Autores principales: McCloy, Rachael A, Rogers, Samuel, Caldon, C Elizabeth, Lorca, Thierry, Castro, Anna, Burgess, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050138/
https://www.ncbi.nlm.nih.gov/pubmed/24626186
http://dx.doi.org/10.4161/cc.28401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050138/
https://www.ncbi.nlm.nih.gov/pubmed/24626186
http://dx.doi.org/10.4161/cc.28401

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