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Partial inhibition of Cdk1 in G(2) phase overrides the SAC and decouples mitotic events
Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G(2) phase onwards. Addition of low doses of RO3306 in G(2) phase induced minor chro...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050138/ https://www.ncbi.nlm.nih.gov/pubmed/24626186 http://dx.doi.org/10.4161/cc.28401 |