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TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres

Telomeres are repetitive nucleoprotein structures at the ends of chromosomes. Like most genomic regions consisting of repetitive DNA, telomeres are fragile sites prone to replication fork stalling and generation of chromosomal instability. In particular, abrogation of the TRF1 telomere binding prote...

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Detalles Bibliográficos
Autores principales:	d’Alcontres, Martina Stagno, Palacios, Jose Alejandro, Mejias, Diego, Blasco, Maria A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050144/ https://www.ncbi.nlm.nih.gov/pubmed/24626180 http://dx.doi.org/10.4161/cc.28419

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