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Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling
Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results in acti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050181/ https://www.ncbi.nlm.nih.gov/pubmed/24918049 http://dx.doi.org/10.1016/j.fob.2014.03.012 |
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author | Santhekadur, Prasanna K. Akiel, Maaged Emdad, Luni Gredler, Rachel Srivastava, Jyoti Rajasekaran, Devaraja Robertson, Chadia L. Mukhopadhyay, Nitai D. Fisher, Paul B. Sarkar, Devanand |
author_facet | Santhekadur, Prasanna K. Akiel, Maaged Emdad, Luni Gredler, Rachel Srivastava, Jyoti Rajasekaran, Devaraja Robertson, Chadia L. Mukhopadhyay, Nitai D. Fisher, Paul B. Sarkar, Devanand |
author_sort | Santhekadur, Prasanna K. |
collection | PubMed |
description | Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results in activation of ERK, Smad2 and subsequently the TGFβ signaling pathway, promoting epithelial–mesenchymal transition (EMT) and migration and invasion by human HCC cells. A positive correlation was observed between SND1 and AT1R expression levels in human HCC patients. Small molecule inhibitors of SND1, alone or in combination with AT1R blockers, might be an effective therapeutic strategy for late-stage aggressive HCC. |
format | Online Article Text |
id | pubmed-4050181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-40501812014-06-10 Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling Santhekadur, Prasanna K. Akiel, Maaged Emdad, Luni Gredler, Rachel Srivastava, Jyoti Rajasekaran, Devaraja Robertson, Chadia L. Mukhopadhyay, Nitai D. Fisher, Paul B. Sarkar, Devanand FEBS Open Bio Article Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results in activation of ERK, Smad2 and subsequently the TGFβ signaling pathway, promoting epithelial–mesenchymal transition (EMT) and migration and invasion by human HCC cells. A positive correlation was observed between SND1 and AT1R expression levels in human HCC patients. Small molecule inhibitors of SND1, alone or in combination with AT1R blockers, might be an effective therapeutic strategy for late-stage aggressive HCC. Elsevier 2014-04-01 /pmc/articles/PMC4050181/ /pubmed/24918049 http://dx.doi.org/10.1016/j.fob.2014.03.012 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Article Santhekadur, Prasanna K. Akiel, Maaged Emdad, Luni Gredler, Rachel Srivastava, Jyoti Rajasekaran, Devaraja Robertson, Chadia L. Mukhopadhyay, Nitai D. Fisher, Paul B. Sarkar, Devanand Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling |
title | Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling |
title_full | Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling |
title_fullStr | Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling |
title_full_unstemmed | Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling |
title_short | Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling |
title_sort | staphylococcal nuclease domain containing-1 (snd1) promotes migration and invasion via angiotensin ii type 1 receptor (at1r) and tgfβ signaling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050181/ https://www.ncbi.nlm.nih.gov/pubmed/24918049 http://dx.doi.org/10.1016/j.fob.2014.03.012 |
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