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The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation
The nuclear receptor, REV-ERBα, has a key role in circadian rhythms and requires heme as its ligand. The present study determined whether the heme precursor, 5-aminolevulinic acid (ALA), affects REV-ERBα and its target genes. When exposed to ALA, the human lung diploid cell line, WI-38, exhibited ac...
Autores principales: | Yamashita, Kohei, Hagiya, Yuichiro, Nakajima, Motowo, Ishizuka, Masahiro, Tanaka, Tohru, Ogura, Shun-ichiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050196/ https://www.ncbi.nlm.nih.gov/pubmed/24918048 http://dx.doi.org/10.1016/j.fob.2014.03.010 |
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