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The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation

The nuclear receptor, REV-ERBα, has a key role in circadian rhythms and requires heme as its ligand. The present study determined whether the heme precursor, 5-aminolevulinic acid (ALA), affects REV-ERBα and its target genes. When exposed to ALA, the human lung diploid cell line, WI-38, exhibited ac...

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Detalles Bibliográficos
Autores principales:	Yamashita, Kohei, Hagiya, Yuichiro, Nakajima, Motowo, Ishizuka, Masahiro, Tanaka, Tohru, Ogura, Shun-ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050196/ https://www.ncbi.nlm.nih.gov/pubmed/24918048 http://dx.doi.org/10.1016/j.fob.2014.03.010

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