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In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study

The brainstem (BS) is involved in critical physiologic processes, including control of cardiovascular and respiratory functions. This study implements a multi-inversion time pulsed arterial spin labelling (MTI PASL) imaging sequence that addresses the challenges of BS imaging and aims to measure nor...

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Autores principales: Warnert, Esther AH, Harris, Ashley D, Murphy, Kevin, Saxena, Neeraj, Tailor, Neeta, Jenkins, Nigel S, Hall, Judith E, Wise, Richard G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050237/
https://www.ncbi.nlm.nih.gov/pubmed/24594624
http://dx.doi.org/10.1038/jcbfm.2014.39
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author Warnert, Esther AH
Harris, Ashley D
Murphy, Kevin
Saxena, Neeraj
Tailor, Neeta
Jenkins, Nigel S
Hall, Judith E
Wise, Richard G
author_facet Warnert, Esther AH
Harris, Ashley D
Murphy, Kevin
Saxena, Neeraj
Tailor, Neeta
Jenkins, Nigel S
Hall, Judith E
Wise, Richard G
author_sort Warnert, Esther AH
collection PubMed
description The brainstem (BS) is involved in critical physiologic processes, including control of cardiovascular and respiratory functions. This study implements a multi-inversion time pulsed arterial spin labelling (MTI PASL) imaging sequence that addresses the challenges of BS imaging and aims to measure normal and elevated BS perfusion in healthy volunteers. An initial experiment was performed to obtain the kinetic curve of the label in the BS and consequently to estimate the label arrival times and tissue perfusion in seven participants. A second experiment estimated the BS cerebral vascular reactivity (CVR) to hypercapnia in 10 participants. Images were acquired with a gradient-echo sequence with two spiral interleaves and short echo time (TE=2.7 ms). Data were analyzed with a two-compartment model, including a tissue and arterial component. In both experiments, perfusion in the BS was significantly lower than in cortical gray matter (repeated measures analysis of variance (RM-ANOVA), P<0.05), which is as expected since the BS consists of gray and white matter, the latter typically showing lower perfusion. The BS CVR found here is comparable to previous reports obtained with positron emission tomography (PET) imaging. Multi-inversion time pulsed ASL in combination with a two-compartment signal model can be used to assess BS perfusion and CVR.
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spelling pubmed-40502372014-06-11 In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study Warnert, Esther AH Harris, Ashley D Murphy, Kevin Saxena, Neeraj Tailor, Neeta Jenkins, Nigel S Hall, Judith E Wise, Richard G J Cereb Blood Flow Metab Original Article The brainstem (BS) is involved in critical physiologic processes, including control of cardiovascular and respiratory functions. This study implements a multi-inversion time pulsed arterial spin labelling (MTI PASL) imaging sequence that addresses the challenges of BS imaging and aims to measure normal and elevated BS perfusion in healthy volunteers. An initial experiment was performed to obtain the kinetic curve of the label in the BS and consequently to estimate the label arrival times and tissue perfusion in seven participants. A second experiment estimated the BS cerebral vascular reactivity (CVR) to hypercapnia in 10 participants. Images were acquired with a gradient-echo sequence with two spiral interleaves and short echo time (TE=2.7 ms). Data were analyzed with a two-compartment model, including a tissue and arterial component. In both experiments, perfusion in the BS was significantly lower than in cortical gray matter (repeated measures analysis of variance (RM-ANOVA), P<0.05), which is as expected since the BS consists of gray and white matter, the latter typically showing lower perfusion. The BS CVR found here is comparable to previous reports obtained with positron emission tomography (PET) imaging. Multi-inversion time pulsed ASL in combination with a two-compartment signal model can be used to assess BS perfusion and CVR. Nature Publishing Group 2014-06 2014-03-05 /pmc/articles/PMC4050237/ /pubmed/24594624 http://dx.doi.org/10.1038/jcbfm.2014.39 Text en Copyright © 2014 International Society for Cerebral Blood Flow & Metabolism, Inc. http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Original Article
Warnert, Esther AH
Harris, Ashley D
Murphy, Kevin
Saxena, Neeraj
Tailor, Neeta
Jenkins, Nigel S
Hall, Judith E
Wise, Richard G
In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
title In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
title_full In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
title_fullStr In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
title_full_unstemmed In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
title_short In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
title_sort in vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050237/
https://www.ncbi.nlm.nih.gov/pubmed/24594624
http://dx.doi.org/10.1038/jcbfm.2014.39
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