Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

Aβ oligomers (AβOs) are crucially involved in Alzheimer’s Disease (AD). However, the lack of selective approaches for targeting these polymorphic Aβ assemblies represents a major hurdle in understanding their biosynthesis, traffic and actions in living cells. Here, we established a subcellularly loc...

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Detalles Bibliográficos
Autores principales: Meli, Giovanni, Lecci, Agnese, Manca, Annalisa, Krako, Nina, Albertini, Valentina, Benussi, Luisa, Ghidoni, Roberta, Cattaneo, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050278/
https://www.ncbi.nlm.nih.gov/pubmed/24861166
http://dx.doi.org/10.1038/ncomms4867

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