Role of Interleukin-22 in liver diseases

INTRODUCTION: Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local...

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Detalles Bibliográficos
Autores principales: Pan, Chun-xiao, Tang, Jie, Wang, Xiao-yu, Wu, Fan-rong, Ge, Jin-fang, Chen, Fei-hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050291/
https://www.ncbi.nlm.nih.gov/pubmed/24623532
http://dx.doi.org/10.1007/s00011-014-0727-3
Descripción
Sumario:INTRODUCTION: Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others. MATERIALS AND METHODS: A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases. CONCLUSION: IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.

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