Role of Interleukin-22 in liver diseases

INTRODUCTION: Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local...

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Autores principales: Pan, Chun-xiao, Tang, Jie, Wang, Xiao-yu, Wu, Fan-rong, Ge, Jin-fang, Chen, Fei-hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050291/
https://www.ncbi.nlm.nih.gov/pubmed/24623532
http://dx.doi.org/10.1007/s00011-014-0727-3
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author Pan, Chun-xiao
Tang, Jie
Wang, Xiao-yu
Wu, Fan-rong
Ge, Jin-fang
Chen, Fei-hu
author_facet Pan, Chun-xiao
Tang, Jie
Wang, Xiao-yu
Wu, Fan-rong
Ge, Jin-fang
Chen, Fei-hu
author_sort Pan, Chun-xiao
collection PubMed
description INTRODUCTION: Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others. MATERIALS AND METHODS: A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases. CONCLUSION: IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.
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spelling pubmed-40502912014-06-18 Role of Interleukin-22 in liver diseases Pan, Chun-xiao Tang, Jie Wang, Xiao-yu Wu, Fan-rong Ge, Jin-fang Chen, Fei-hu Inflamm Res Review INTRODUCTION: Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others. MATERIALS AND METHODS: A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases. CONCLUSION: IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases. Springer Basel 2014-03-13 2014 /pmc/articles/PMC4050291/ /pubmed/24623532 http://dx.doi.org/10.1007/s00011-014-0727-3 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Pan, Chun-xiao
Tang, Jie
Wang, Xiao-yu
Wu, Fan-rong
Ge, Jin-fang
Chen, Fei-hu
Role of Interleukin-22 in liver diseases
title Role of Interleukin-22 in liver diseases
title_full Role of Interleukin-22 in liver diseases
title_fullStr Role of Interleukin-22 in liver diseases
title_full_unstemmed Role of Interleukin-22 in liver diseases
title_short Role of Interleukin-22 in liver diseases
title_sort role of interleukin-22 in liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050291/
https://www.ncbi.nlm.nih.gov/pubmed/24623532
http://dx.doi.org/10.1007/s00011-014-0727-3
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