Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana

Five new guanacastane-type diterpenes, named guanacastepenes P–T (1–5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11...

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Detalles Bibliográficos
Autores principales: Yin, Xia, Feng, Tao, Li, Zheng-Hui, Leng, Ying, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050309/
https://www.ncbi.nlm.nih.gov/pubmed/24955296
http://dx.doi.org/10.1007/s13659-014-0020-8
Descripción
Sumario:Five new guanacastane-type diterpenes, named guanacastepenes P–T (1–5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC(50) values of 6.2 and 13.9 μM, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0020-8) contains supplementary material, which is available to authorized users.

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