Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana

Five new guanacastane-type diterpenes, named guanacastepenes P–T (1–5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11...

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Detalles Bibliográficos
Autores principales: Yin, Xia, Feng, Tao, Li, Zheng-Hui, Leng, Ying, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050309/
https://www.ncbi.nlm.nih.gov/pubmed/24955296
http://dx.doi.org/10.1007/s13659-014-0020-8
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author Yin, Xia
Feng, Tao
Li, Zheng-Hui
Leng, Ying
Liu, Ji-Kai
author_facet Yin, Xia
Feng, Tao
Li, Zheng-Hui
Leng, Ying
Liu, Ji-Kai
author_sort Yin, Xia
collection PubMed
description Five new guanacastane-type diterpenes, named guanacastepenes P–T (1–5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC(50) values of 6.2 and 13.9 μM, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0020-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-40503092014-06-18 Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana Yin, Xia Feng, Tao Li, Zheng-Hui Leng, Ying Liu, Ji-Kai Nat Prod Bioprospect Original Article Five new guanacastane-type diterpenes, named guanacastepenes P–T (1–5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC(50) values of 6.2 and 13.9 μM, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0020-8) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-05-08 /pmc/articles/PMC4050309/ /pubmed/24955296 http://dx.doi.org/10.1007/s13659-014-0020-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Yin, Xia
Feng, Tao
Li, Zheng-Hui
Leng, Ying
Liu, Ji-Kai
Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana
title Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana
title_full Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana
title_fullStr Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana
title_full_unstemmed Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana
title_short Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana
title_sort five new guanacastane-type diterpenes from cultures of the fungus psathyrella candolleana
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050309/
https://www.ncbi.nlm.nih.gov/pubmed/24955296
http://dx.doi.org/10.1007/s13659-014-0020-8
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