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Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes

Type 1 diabetes (T1D) is a multigenic disease caused by T-cell mediated destruction of the insulin producing pancreatic islet ß-cells. The earliest sign of islet autoimmunity in NOD mice, islet leukocytic infiltration or insulitis, is obvious at around 5 weeks of age. The molecular alterations that...

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Detalles Bibliográficos
Autores principales:	Kakoola, Dorothy N., Curcio-Brint, Anita, Lenchik, Nataliya I., Gerling, Ivan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050318/ https://www.ncbi.nlm.nih.gov/pubmed/24918037 http://dx.doi.org/10.1016/j.rinim.2014.05.001

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