Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have funct...

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Detalles Bibliográficos
Autores principales: Lombardi, Sara, Honeth, Gabriella, Ginestier, Christophe, Shinomiya, Ireneusz, Marlow, Rebecca, Buchupalli, Bharath, Gazinska, Patrycja, Brown, John, Catchpole, Steven, Liu, Suling, Barkan, Ariel, Wicha, Max, Purushotham, Anand, Burchell, Joy, Pinder, Sarah, Dontu, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050343/
https://www.ncbi.nlm.nih.gov/pubmed/24936466
http://dx.doi.org/10.1016/j.stemcr.2014.05.005
Descripción
Sumario:Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

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