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Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells
Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have funct...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050343/ https://www.ncbi.nlm.nih.gov/pubmed/24936466 http://dx.doi.org/10.1016/j.stemcr.2014.05.005 |
| _version_ | 1782319940083122176 |
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| author | Lombardi, Sara Honeth, Gabriella Ginestier, Christophe Shinomiya, Ireneusz Marlow, Rebecca Buchupalli, Bharath Gazinska, Patrycja Brown, John Catchpole, Steven Liu, Suling Barkan, Ariel Wicha, Max Purushotham, Anand Burchell, Joy Pinder, Sarah Dontu, Gabriela |
| author_facet | Lombardi, Sara Honeth, Gabriella Ginestier, Christophe Shinomiya, Ireneusz Marlow, Rebecca Buchupalli, Bharath Gazinska, Patrycja Brown, John Catchpole, Steven Liu, Suling Barkan, Ariel Wicha, Max Purushotham, Anand Burchell, Joy Pinder, Sarah Dontu, Gabriela |
| author_sort | Lombardi, Sara |
| collection | PubMed |
| description | Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development. |
| format | Online Article Text |
| id | pubmed-4050343 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40503432014-06-16 Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells Lombardi, Sara Honeth, Gabriella Ginestier, Christophe Shinomiya, Ireneusz Marlow, Rebecca Buchupalli, Bharath Gazinska, Patrycja Brown, John Catchpole, Steven Liu, Suling Barkan, Ariel Wicha, Max Purushotham, Anand Burchell, Joy Pinder, Sarah Dontu, Gabriela Stem Cell Reports Article Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development. Elsevier 2014-06-03 /pmc/articles/PMC4050343/ /pubmed/24936466 http://dx.doi.org/10.1016/j.stemcr.2014.05.005 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| spellingShingle | Article Lombardi, Sara Honeth, Gabriella Ginestier, Christophe Shinomiya, Ireneusz Marlow, Rebecca Buchupalli, Bharath Gazinska, Patrycja Brown, John Catchpole, Steven Liu, Suling Barkan, Ariel Wicha, Max Purushotham, Anand Burchell, Joy Pinder, Sarah Dontu, Gabriela Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells |
| title | Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells |
| title_full | Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells |
| title_fullStr | Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells |
| title_full_unstemmed | Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells |
| title_short | Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells |
| title_sort | growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050343/ https://www.ncbi.nlm.nih.gov/pubmed/24936466 http://dx.doi.org/10.1016/j.stemcr.2014.05.005 |
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