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Looking for new treatments of Infantile Colic

Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue mainly becaus...

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Autores principales: Savino, Francesco, Ceratto, Simone, De Marco, Angela, Cordero di Montezemolo, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050441/
https://www.ncbi.nlm.nih.gov/pubmed/24898541
http://dx.doi.org/10.1186/1824-7288-40-53
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author Savino, Francesco
Ceratto, Simone
De Marco, Angela
Cordero di Montezemolo, Luca
author_facet Savino, Francesco
Ceratto, Simone
De Marco, Angela
Cordero di Montezemolo, Luca
author_sort Savino, Francesco
collection PubMed
description Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue mainly because of the lack of evidence based medicine guidelines. Up to now, there is no consensus concerning management and treatment. Literature reports growing evidence about the effectiveness of dietary, pharmacological, complementary and behavioral therapies as options for the management of infantile colic. Dietary approach, usually based on the avoidance of cow’s milk proteins in breast-feeding mothers and bottle-fed infants, more recently has seen the rise of new special formulas, such as partially hydrolyzed proteins and low lactose added with prebiotics or probiotics: their efficacy needs to be further documented. Investigated pharmacological agents are Simethicone and Cimetropium Bromide: the first is able to reduce bloating while the second could reduce fussing crying, but it has been tested only for severe infantile colic. No other pain relieving agents have been proposed until now, but some clinical trials are ongoing for new drugs. There is limited evidence supporting the use of complementary and alternative treatments (herbal supplements, manipulative approach and acupuncture) or behavioral interventions. Recent studies have focused the role of microbiota in the pathogenesis of this disturb and so new treatments, such as probiotics, have been proposed, but only few strains have been tested. Further investigations are needed in order to provide evidence-based guidelines.
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spelling pubmed-40504412014-06-11 Looking for new treatments of Infantile Colic Savino, Francesco Ceratto, Simone De Marco, Angela Cordero di Montezemolo, Luca Ital J Pediatr Review Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue mainly because of the lack of evidence based medicine guidelines. Up to now, there is no consensus concerning management and treatment. Literature reports growing evidence about the effectiveness of dietary, pharmacological, complementary and behavioral therapies as options for the management of infantile colic. Dietary approach, usually based on the avoidance of cow’s milk proteins in breast-feeding mothers and bottle-fed infants, more recently has seen the rise of new special formulas, such as partially hydrolyzed proteins and low lactose added with prebiotics or probiotics: their efficacy needs to be further documented. Investigated pharmacological agents are Simethicone and Cimetropium Bromide: the first is able to reduce bloating while the second could reduce fussing crying, but it has been tested only for severe infantile colic. No other pain relieving agents have been proposed until now, but some clinical trials are ongoing for new drugs. There is limited evidence supporting the use of complementary and alternative treatments (herbal supplements, manipulative approach and acupuncture) or behavioral interventions. Recent studies have focused the role of microbiota in the pathogenesis of this disturb and so new treatments, such as probiotics, have been proposed, but only few strains have been tested. Further investigations are needed in order to provide evidence-based guidelines. BioMed Central 2014-06-05 /pmc/articles/PMC4050441/ /pubmed/24898541 http://dx.doi.org/10.1186/1824-7288-40-53 Text en Copyright © 2014 Savino et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Savino, Francesco
Ceratto, Simone
De Marco, Angela
Cordero di Montezemolo, Luca
Looking for new treatments of Infantile Colic
title Looking for new treatments of Infantile Colic
title_full Looking for new treatments of Infantile Colic
title_fullStr Looking for new treatments of Infantile Colic
title_full_unstemmed Looking for new treatments of Infantile Colic
title_short Looking for new treatments of Infantile Colic
title_sort looking for new treatments of infantile colic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050441/
https://www.ncbi.nlm.nih.gov/pubmed/24898541
http://dx.doi.org/10.1186/1824-7288-40-53
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