Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

BACKGROUND: Alzheimer’s disease (AD) pathology occurs in part as the result of excessive production of β-amyloid (Aβ). Metabotropic glutamate receptor 5 (mGluR5) is now considered a receptor for Aβ and consequently contributes to pathogenic Aβ signaling in AD. RESULTS: Genetic deletion of mGluR5 res...

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Detalles Bibliográficos
Autores principales: Hamilton, Alison, Esseltine, Jessica L, DeVries, Rebecca A, Cregan, Sean P, Ferguson, Stephen S G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050478/
https://www.ncbi.nlm.nih.gov/pubmed/24886239
http://dx.doi.org/10.1186/1756-6606-7-40

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