Rab18 and a Rab18 GEF complex are required for normal ER structure

The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro syndrome. Here, we demonstrate that the Rab3GAP complex is a specific Rab18 guanine nucleotide exchange factor (GEF). The Rab3GAP complex localizes t...

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Detalles Bibliográficos
Autores principales: Gerondopoulos, Andreas, Bastos, Ricardo Nunes, Yoshimura, Shin-ichiro, Anderson, Rachel, Carpanini, Sarah, Aligianis, Irene, Handley, Mark T., Barr, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050724/
https://www.ncbi.nlm.nih.gov/pubmed/24891604
http://dx.doi.org/10.1083/jcb.201403026

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