Poly(ADP-ribose): An organizer of cellular architecture

Distinct properties of poly(ADP-ribose)—including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature—could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structure...

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Detalles Bibliográficos
Autor principal: Leung, Anthony K.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050725/
https://www.ncbi.nlm.nih.gov/pubmed/24914234
http://dx.doi.org/10.1083/jcb.201402114
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author Leung, Anthony K.L.
author_facet Leung, Anthony K.L.
author_sort Leung, Anthony K.L.
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description Distinct properties of poly(ADP-ribose)—including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature—could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADP-ribose) could direct cellular organization.
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spelling pubmed-40507252014-12-09 Poly(ADP-ribose): An organizer of cellular architecture Leung, Anthony K.L. J Cell Biol Reviews Distinct properties of poly(ADP-ribose)—including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature—could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADP-ribose) could direct cellular organization. The Rockefeller University Press 2014-06-09 /pmc/articles/PMC4050725/ /pubmed/24914234 http://dx.doi.org/10.1083/jcb.201402114 Text en © 2014 Leung This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Leung, Anthony K.L.
Poly(ADP-ribose): An organizer of cellular architecture
title Poly(ADP-ribose): An organizer of cellular architecture
title_full Poly(ADP-ribose): An organizer of cellular architecture
title_fullStr Poly(ADP-ribose): An organizer of cellular architecture
title_full_unstemmed Poly(ADP-ribose): An organizer of cellular architecture
title_short Poly(ADP-ribose): An organizer of cellular architecture
title_sort poly(adp-ribose): an organizer of cellular architecture
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050725/
https://www.ncbi.nlm.nih.gov/pubmed/24914234
http://dx.doi.org/10.1083/jcb.201402114
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