miR-639 promotes the proliferation and invasion of breast cancer cell in vitro

Breast cancer is characterised by an elevated capacity for tumour invasion and lymph node metastasis, but the cause remains to be determined. Recent studies suggest that microRNAs can regulate the evolution of malignant behaviours by regulating multiple target genes. In this study, we have first con...

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Detalles Bibliográficos
Autores principales: Li, Lin, Qiu, Xin-guang, Lv, Peng-wei, Wang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050991/
https://www.ncbi.nlm.nih.gov/pubmed/24917697
http://dx.doi.org/10.1186/1475-2867-14-39
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author Li, Lin
Qiu, Xin-guang
Lv, Peng-wei
Wang, Fang
author_facet Li, Lin
Qiu, Xin-guang
Lv, Peng-wei
Wang, Fang
author_sort Li, Lin
collection PubMed
description Breast cancer is characterised by an elevated capacity for tumour invasion and lymph node metastasis, but the cause remains to be determined. Recent studies suggest that microRNAs can regulate the evolution of malignant behaviours by regulating multiple target genes. In this study, we have first confirmed that miR-639 is up-regulated in metastatic breast cancer tissues and cell line with highly invasive capacity. Furthermore, we provided evidence to demonstrate that up-regulation of miR-639 contributes breast cancer invasion and metastasis. These data reveal a key role of miR-639 in breast cancer metastasis and support biological and clinical links between miR-639 and breast cancer.
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spelling pubmed-40509912014-06-11 miR-639 promotes the proliferation and invasion of breast cancer cell in vitro Li, Lin Qiu, Xin-guang Lv, Peng-wei Wang, Fang Cancer Cell Int Primary Research Breast cancer is characterised by an elevated capacity for tumour invasion and lymph node metastasis, but the cause remains to be determined. Recent studies suggest that microRNAs can regulate the evolution of malignant behaviours by regulating multiple target genes. In this study, we have first confirmed that miR-639 is up-regulated in metastatic breast cancer tissues and cell line with highly invasive capacity. Furthermore, we provided evidence to demonstrate that up-regulation of miR-639 contributes breast cancer invasion and metastasis. These data reveal a key role of miR-639 in breast cancer metastasis and support biological and clinical links between miR-639 and breast cancer. BioMed Central 2014-05-10 /pmc/articles/PMC4050991/ /pubmed/24917697 http://dx.doi.org/10.1186/1475-2867-14-39 Text en Copyright © 2014 Li et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Primary Research
Li, Lin
Qiu, Xin-guang
Lv, Peng-wei
Wang, Fang
miR-639 promotes the proliferation and invasion of breast cancer cell in vitro
title miR-639 promotes the proliferation and invasion of breast cancer cell in vitro
title_full miR-639 promotes the proliferation and invasion of breast cancer cell in vitro
title_fullStr miR-639 promotes the proliferation and invasion of breast cancer cell in vitro
title_full_unstemmed miR-639 promotes the proliferation and invasion of breast cancer cell in vitro
title_short miR-639 promotes the proliferation and invasion of breast cancer cell in vitro
title_sort mir-639 promotes the proliferation and invasion of breast cancer cell in vitro
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050991/
https://www.ncbi.nlm.nih.gov/pubmed/24917697
http://dx.doi.org/10.1186/1475-2867-14-39
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