Buprenorphine

In the crystal structure of a semi-synthetic opioid drug buprenorphine, C(29)H(41)NO(4) {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclo­propyl­methyl-3-hy­droxy-6-meth­oxy-4,5-ep­oxy-6,14-ethano­morphinan-7-yl]-3,3-di­methyl­butan-2-ol}, the cyclo­propyl­methyl group is disordered over two sites w...

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Detalles Bibliográficos
Autores principales: Mazurek, Jaroslaw, Hoffmann, Marcel, Fernandez Casares, Anna, Cox, Phillip D., Minardi, Mathew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051008/
https://www.ncbi.nlm.nih.gov/pubmed/24940223
http://dx.doi.org/10.1107/S1600536814009672
Descripción
Sumario:In the crystal structure of a semi-synthetic opioid drug buprenorphine, C(29)H(41)NO(4) {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclo­propyl­methyl-3-hy­droxy-6-meth­oxy-4,5-ep­oxy-6,14-ethano­morphinan-7-yl]-3,3-di­methyl­butan-2-ol}, the cyclo­propyl­methyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hy­droxy groups is involved in intra­molecular O—H⋯O hydrogen bond. The other hy­droxy group acts as a proton donor in an inter­molecular O—H⋯O inter­action that connects mol­ecules into a zigzag chain along the b axis.

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