Buprenorphine

In the crystal structure of a semi-synthetic opioid drug buprenorphine, C(29)H(41)NO(4) {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclo­propyl­methyl-3-hy­droxy-6-meth­oxy-4,5-ep­oxy-6,14-ethano­morphinan-7-yl]-3,3-di­methyl­butan-2-ol}, the cyclo­propyl­methyl group is disordered over two sites w...

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Autores principales: Mazurek, Jaroslaw, Hoffmann, Marcel, Fernandez Casares, Anna, Cox, Phillip D., Minardi, Mathew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051008/
https://www.ncbi.nlm.nih.gov/pubmed/24940223
http://dx.doi.org/10.1107/S1600536814009672
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author Mazurek, Jaroslaw
Hoffmann, Marcel
Fernandez Casares, Anna
Cox, Phillip D.
Minardi, Mathew D.
author_facet Mazurek, Jaroslaw
Hoffmann, Marcel
Fernandez Casares, Anna
Cox, Phillip D.
Minardi, Mathew D.
author_sort Mazurek, Jaroslaw
collection PubMed
description In the crystal structure of a semi-synthetic opioid drug buprenorphine, C(29)H(41)NO(4) {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclo­propyl­methyl-3-hy­droxy-6-meth­oxy-4,5-ep­oxy-6,14-ethano­morphinan-7-yl]-3,3-di­methyl­butan-2-ol}, the cyclo­propyl­methyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hy­droxy groups is involved in intra­molecular O—H⋯O hydrogen bond. The other hy­droxy group acts as a proton donor in an inter­molecular O—H⋯O inter­action that connects mol­ecules into a zigzag chain along the b axis.
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spelling pubmed-40510082014-06-17 Buprenorphine Mazurek, Jaroslaw Hoffmann, Marcel Fernandez Casares, Anna Cox, Phillip D. Minardi, Mathew D. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal structure of a semi-synthetic opioid drug buprenorphine, C(29)H(41)NO(4) {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclo­propyl­methyl-3-hy­droxy-6-meth­oxy-4,5-ep­oxy-6,14-ethano­morphinan-7-yl]-3,3-di­methyl­butan-2-ol}, the cyclo­propyl­methyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hy­droxy groups is involved in intra­molecular O—H⋯O hydrogen bond. The other hy­droxy group acts as a proton donor in an inter­molecular O—H⋯O inter­action that connects mol­ecules into a zigzag chain along the b axis. International Union of Crystallography 2014-05-03 /pmc/articles/PMC4051008/ /pubmed/24940223 http://dx.doi.org/10.1107/S1600536814009672 Text en © Mazurek et al. 2014 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Mazurek, Jaroslaw
Hoffmann, Marcel
Fernandez Casares, Anna
Cox, Phillip D.
Minardi, Mathew D.
Buprenorphine
title Buprenorphine
title_full Buprenorphine
title_fullStr Buprenorphine
title_full_unstemmed Buprenorphine
title_short Buprenorphine
title_sort buprenorphine
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051008/
https://www.ncbi.nlm.nih.gov/pubmed/24940223
http://dx.doi.org/10.1107/S1600536814009672
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