Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

The M2-1 protein of human metapneumovirus (HMPV) is a zinc-binding transcription antiterminator which is highly conserved among pneumoviruses. We report the structure of tetrameric HMPV M2-1. Each protomer features a N-terminal zinc finger domain and an α-helical tetramerization motif forming a rigi...

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Detalles Bibliográficos
Autores principales: Leyrat, Cedric, Renner, Max, Harlos, Karl, Huiskonen, Juha T, Grimes, Jonathan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051120/
https://www.ncbi.nlm.nih.gov/pubmed/24842877
http://dx.doi.org/10.7554/eLife.02674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051120/
https://www.ncbi.nlm.nih.gov/pubmed/24842877
http://dx.doi.org/10.7554/eLife.02674

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