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Immunotherapy for Alzheimer’s disease: past, present and future
Alzheimer’s disease (AD) is an incurable, progressive, neurodegenerative disorder affecting over 5 million people in the US alone. This neurological disorder is characterized by widespread neurodegeneration throughout the association cortex and limbic system caused by deposition of Aβ resulting in t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051211/ https://www.ncbi.nlm.nih.gov/pubmed/24959143 http://dx.doi.org/10.3389/fnagi.2014.00114 |
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author | Spencer, Brian Masliah, Eliezer |
author_facet | Spencer, Brian Masliah, Eliezer |
author_sort | Spencer, Brian |
collection | PubMed |
description | Alzheimer’s disease (AD) is an incurable, progressive, neurodegenerative disorder affecting over 5 million people in the US alone. This neurological disorder is characterized by widespread neurodegeneration throughout the association cortex and limbic system caused by deposition of Aβ resulting in the formation of plaques and tau resulting in the formation of neurofibrillary tangles. Active immunization for Aβ showed promise in animal models of AD; however, the models were unable to predict the off-target immune effects in human patients. A few patients in the initial trial suffered cerebral meningoencephalitis. Recently, passive immunization has shown promise in the lab with less chance of off-target immune effects. Several trials have attempted using passive immunization for Aβ, but again, positive end points have been elusive. The next generation of immunotherapy for AD may involve the marriage of anti-Aβ antibodies with technology aimed at improving transport across the blood-brain barrier (BBB). Receptor mediated transport of antibodies may increase CNS exposure and improve the therapeutic index in the clinic. |
format | Online Article Text |
id | pubmed-4051211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40512112014-06-23 Immunotherapy for Alzheimer’s disease: past, present and future Spencer, Brian Masliah, Eliezer Front Aging Neurosci Neuroscience Alzheimer’s disease (AD) is an incurable, progressive, neurodegenerative disorder affecting over 5 million people in the US alone. This neurological disorder is characterized by widespread neurodegeneration throughout the association cortex and limbic system caused by deposition of Aβ resulting in the formation of plaques and tau resulting in the formation of neurofibrillary tangles. Active immunization for Aβ showed promise in animal models of AD; however, the models were unable to predict the off-target immune effects in human patients. A few patients in the initial trial suffered cerebral meningoencephalitis. Recently, passive immunization has shown promise in the lab with less chance of off-target immune effects. Several trials have attempted using passive immunization for Aβ, but again, positive end points have been elusive. The next generation of immunotherapy for AD may involve the marriage of anti-Aβ antibodies with technology aimed at improving transport across the blood-brain barrier (BBB). Receptor mediated transport of antibodies may increase CNS exposure and improve the therapeutic index in the clinic. Frontiers Media S.A. 2014-06-10 /pmc/articles/PMC4051211/ /pubmed/24959143 http://dx.doi.org/10.3389/fnagi.2014.00114 Text en Copyright © 2014 Spencer and Masliah. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Spencer, Brian Masliah, Eliezer Immunotherapy for Alzheimer’s disease: past, present and future |
title | Immunotherapy for Alzheimer’s disease: past, present and future |
title_full | Immunotherapy for Alzheimer’s disease: past, present and future |
title_fullStr | Immunotherapy for Alzheimer’s disease: past, present and future |
title_full_unstemmed | Immunotherapy for Alzheimer’s disease: past, present and future |
title_short | Immunotherapy for Alzheimer’s disease: past, present and future |
title_sort | immunotherapy for alzheimer’s disease: past, present and future |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051211/ https://www.ncbi.nlm.nih.gov/pubmed/24959143 http://dx.doi.org/10.3389/fnagi.2014.00114 |
work_keys_str_mv | AT spencerbrian immunotherapyforalzheimersdiseasepastpresentandfuture AT masliaheliezer immunotherapyforalzheimersdiseasepastpresentandfuture |