Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia

The Notch signaling pathway has been recognized as a key factor for the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), because of the high incidence of activating mutations of Notch1. Notch inhibition could serve as a new treatment strategy for T-ALL; however, the attempts to perturb N...

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Detalles Bibliográficos
Autores principales: Koyama, D, Kikuchi, J, Hiraoka, N, Wada, T, Kurosawa, H, Chiba, S, Furukawa, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051216/
https://www.ncbi.nlm.nih.gov/pubmed/24301524
http://dx.doi.org/10.1038/leu.2013.366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051216/
https://www.ncbi.nlm.nih.gov/pubmed/24301524
http://dx.doi.org/10.1038/leu.2013.366

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