Cargando…
Design and Applications of Bispecific Heterodimers: Molecular Imaging and beyond
[Image: see text] Ligand-based molecular imaging probes have been designed with high affinity and specificity for monitoring biological process and responses. Single-target recognition by traditional probes can limit their applicability for disease detection and therapy because synergistic action be...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051252/ https://www.ncbi.nlm.nih.gov/pubmed/24738564 http://dx.doi.org/10.1021/mp500115x |
_version_ | 1782320081519247360 |
---|---|
author | Luo, Haiming Hong, Hao Yang, Sarah P. Cai, Weibo |
author_facet | Luo, Haiming Hong, Hao Yang, Sarah P. Cai, Weibo |
author_sort | Luo, Haiming |
collection | PubMed |
description | [Image: see text] Ligand-based molecular imaging probes have been designed with high affinity and specificity for monitoring biological process and responses. Single-target recognition by traditional probes can limit their applicability for disease detection and therapy because synergistic action between disease mediators and different receptors is often involved in disease progression. Consequently, probes that can recognize multiple targets should demonstrate higher targeting efficacy and specificity than their monospecific peers. This concept has been validated by multiple bispecific heterodimer-based imaging probes that have demonstrated promising results in several animal models. This review summarizes the design strategies for bispecific peptide- and antibody-based heterodimers and their applications in molecular targeting and imaging. The design and application of bispecific heterodimer-conjugated nanomaterials are also discussed. |
format | Online Article Text |
id | pubmed-4051252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-40512522015-04-16 Design and Applications of Bispecific Heterodimers: Molecular Imaging and beyond Luo, Haiming Hong, Hao Yang, Sarah P. Cai, Weibo Mol Pharm [Image: see text] Ligand-based molecular imaging probes have been designed with high affinity and specificity for monitoring biological process and responses. Single-target recognition by traditional probes can limit their applicability for disease detection and therapy because synergistic action between disease mediators and different receptors is often involved in disease progression. Consequently, probes that can recognize multiple targets should demonstrate higher targeting efficacy and specificity than their monospecific peers. This concept has been validated by multiple bispecific heterodimer-based imaging probes that have demonstrated promising results in several animal models. This review summarizes the design strategies for bispecific peptide- and antibody-based heterodimers and their applications in molecular targeting and imaging. The design and application of bispecific heterodimer-conjugated nanomaterials are also discussed. American Chemical Society 2014-04-16 2014-06-02 /pmc/articles/PMC4051252/ /pubmed/24738564 http://dx.doi.org/10.1021/mp500115x Text en Copyright © 2014 American Chemical Society |
spellingShingle | Luo, Haiming Hong, Hao Yang, Sarah P. Cai, Weibo Design and Applications of Bispecific Heterodimers: Molecular Imaging and beyond |
title | Design and Applications of Bispecific Heterodimers:
Molecular Imaging and beyond |
title_full | Design and Applications of Bispecific Heterodimers:
Molecular Imaging and beyond |
title_fullStr | Design and Applications of Bispecific Heterodimers:
Molecular Imaging and beyond |
title_full_unstemmed | Design and Applications of Bispecific Heterodimers:
Molecular Imaging and beyond |
title_short | Design and Applications of Bispecific Heterodimers:
Molecular Imaging and beyond |
title_sort | design and applications of bispecific heterodimers:
molecular imaging and beyond |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051252/ https://www.ncbi.nlm.nih.gov/pubmed/24738564 http://dx.doi.org/10.1021/mp500115x |
work_keys_str_mv | AT luohaiming designandapplicationsofbispecificheterodimersmolecularimagingandbeyond AT honghao designandapplicationsofbispecificheterodimersmolecularimagingandbeyond AT yangsarahp designandapplicationsofbispecificheterodimersmolecularimagingandbeyond AT caiweibo designandapplicationsofbispecificheterodimersmolecularimagingandbeyond |