Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

[Image: see text] Two mutations of the phosphodianion gripper loop in chicken muscle triosephosphate isomerase (cTIM) were examined: (1) the loop deletion mutant (LDM) formed by removal of residues 170–173 [Pompliano, D. L., et al. (1990) Biochemistry 29, 3186–3194] and (2) the loop 6 replacement mu...

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Autores principales: Zhai, Xiang, Go, Maybelle K., O’Donoghue, AnnMarie C., Amyes, Tina L., Pegan, Scott D., Wang, Yan, Loria, J. Patrick, Mesecar, Andrew D., Richard, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051426/
https://www.ncbi.nlm.nih.gov/pubmed/24825099
http://dx.doi.org/10.1021/bi500458t

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