Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28

The DEAD-box protein Prp28 is essential for pre-mRNA splicing as it plays a key role in the formation of an active spliceosome. Prp28 participates in the release of the U1 snRNP from the 5′-splice site during association of the U5·U4/U6 tri-snRNP, which is a crucial step in the transition from a pre...

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Detalles Bibliográficos
Autores principales: Möhlmann, Sina, Mathew, Rebecca, Neumann, Piotr, Schmitt, Andreas, Lührmann, Reinhard, Ficner, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051504/
https://www.ncbi.nlm.nih.gov/pubmed/24914973
http://dx.doi.org/10.1107/S1399004714006439

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