Stiff-Person Syndrome: Case Series

Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases...

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Detalles Bibliográficos
Autores principales: Jung, Yu Jin, Jeong, Han G., Kim, Ryul, Kim, Han-Joon, Jeon, Beom S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Movement Disorder Society 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051723/
https://www.ncbi.nlm.nih.gov/pubmed/24926406
http://dx.doi.org/10.14802/jmd.14004
Descripción
Sumario:Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases of patients with classical SPS finally confirmed by high serum level of GAD antibodies. All of our patients respond favorably to gamma amino butyric acid-enhancing drugs and immunotherapies.

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