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The Estrogen Hypothesis of Obesity
The explanation of obesity as a simple result of positive energy balance fails to account for the scope of variable responses to diets and lifestyles. It is postulated that individual physiological and anatomical variation may be responsible for developing obesity. Girls in poor families develop gre...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051760/ https://www.ncbi.nlm.nih.gov/pubmed/24915457 http://dx.doi.org/10.1371/journal.pone.0099776 |
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author | Grantham, James P. Henneberg, Maciej |
author_facet | Grantham, James P. Henneberg, Maciej |
author_sort | Grantham, James P. |
collection | PubMed |
description | The explanation of obesity as a simple result of positive energy balance fails to account for the scope of variable responses to diets and lifestyles. It is postulated that individual physiological and anatomical variation may be responsible for developing obesity. Girls in poor families develop greater adiposity than their male siblings, a trend not present in richer environments. This indicates strong influence of estrogen on fat accumulation irrespective of poor socioeconomic conditions. Obesity rates in males and females of developed nations are similar, while in poorer nations obesity is much more prevalent in females. Female to male ratio of obesity correlates inversely with gross domestic product. Therefore, the parity of male and female obesity in developed countries may result from male exposure to environmental estrogen-like substances associated with affluence. These hormonally driven mechanisms may be equally active within both sexes in more developed areas, thereby increasing overall obesity. |
format | Online Article Text |
id | pubmed-4051760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40517602014-06-18 The Estrogen Hypothesis of Obesity Grantham, James P. Henneberg, Maciej PLoS One Research Article The explanation of obesity as a simple result of positive energy balance fails to account for the scope of variable responses to diets and lifestyles. It is postulated that individual physiological and anatomical variation may be responsible for developing obesity. Girls in poor families develop greater adiposity than their male siblings, a trend not present in richer environments. This indicates strong influence of estrogen on fat accumulation irrespective of poor socioeconomic conditions. Obesity rates in males and females of developed nations are similar, while in poorer nations obesity is much more prevalent in females. Female to male ratio of obesity correlates inversely with gross domestic product. Therefore, the parity of male and female obesity in developed countries may result from male exposure to environmental estrogen-like substances associated with affluence. These hormonally driven mechanisms may be equally active within both sexes in more developed areas, thereby increasing overall obesity. Public Library of Science 2014-06-10 /pmc/articles/PMC4051760/ /pubmed/24915457 http://dx.doi.org/10.1371/journal.pone.0099776 Text en © 2014 Grantham, Henneberg http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Grantham, James P. Henneberg, Maciej The Estrogen Hypothesis of Obesity |
title | The Estrogen Hypothesis of Obesity |
title_full | The Estrogen Hypothesis of Obesity |
title_fullStr | The Estrogen Hypothesis of Obesity |
title_full_unstemmed | The Estrogen Hypothesis of Obesity |
title_short | The Estrogen Hypothesis of Obesity |
title_sort | estrogen hypothesis of obesity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051760/ https://www.ncbi.nlm.nih.gov/pubmed/24915457 http://dx.doi.org/10.1371/journal.pone.0099776 |
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