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The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

Fanconi anaemia (FA) is a cancer predisposition syndrome characterized by cellular sensitivity to DNA interstrand crosslinkers. The molecular defect in FA is an impaired DNA repair pathway. The critical event in activating this pathway is monoubiquitination of FANCD2. In vivo, a multisubunit FA core...

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Detalles Bibliográficos
Autores principales:	Rajendra, Eeson, Oestergaard, Vibe H., Langevin, Frédéric, Wang, Meng, Dornan, Gillian L., Patel, Ketan J., Passmore, Lori A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051986/ https://www.ncbi.nlm.nih.gov/pubmed/24905007 http://dx.doi.org/10.1016/j.molcel.2014.05.001

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