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Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure

AIMS/HYPOTHESIS: Glucokinase (GCK) plays a role in glucose metabolism and glucose-stimulated insulin secretion. Rare mutations in GCK cause MODY. We investigated whether common variation (minor allele frequency ≥0.01) in GCK is associated with metabolic traits and type 2 diabetes. METHODS: Four exon...

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Detalles Bibliográficos
Autores principales:	Muller, Yunhua L., Piaggi, Paolo, Hoffman, Duncan, Huang, Ke, Gene, Brittany, Kobes, Sayuko, Thearle, Marie S., Knowler, William C., Hanson, Robert L., Baier, Leslie J., Bogardus, Clifton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052004/ https://www.ncbi.nlm.nih.gov/pubmed/24728127 http://dx.doi.org/10.1007/s00125-014-3234-8

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