The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder

Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal sympt...

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Detalles Bibliográficos
Autores principales: Kawabe, Kentaro, Horiuchi, Fumie, Oka, Yasunori, Ueno, Shu-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052092/
https://www.ncbi.nlm.nih.gov/pubmed/24955274
http://dx.doi.org/10.1155/2014/561071
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author Kawabe, Kentaro
Horiuchi, Fumie
Oka, Yasunori
Ueno, Shu-ichi
author_facet Kawabe, Kentaro
Horiuchi, Fumie
Oka, Yasunori
Ueno, Shu-ichi
author_sort Kawabe, Kentaro
collection PubMed
description Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal symptoms improved with ramelteon, a selective melatonin receptor agonist. Insomnia and behavior, assessed using the Clinical Global Impression-Improvement Scale, improved in two cases with 2 mg ramelteon and in the third case with 8 mg ramelteon. Our findings demonstrate that ramelteon is effective not only for insomnia, but for behavioral problems as well, in patients with autistic disorder.
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spelling pubmed-40520922014-06-22 The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder Kawabe, Kentaro Horiuchi, Fumie Oka, Yasunori Ueno, Shu-ichi Case Rep Psychiatry Case Report Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal symptoms improved with ramelteon, a selective melatonin receptor agonist. Insomnia and behavior, assessed using the Clinical Global Impression-Improvement Scale, improved in two cases with 2 mg ramelteon and in the third case with 8 mg ramelteon. Our findings demonstrate that ramelteon is effective not only for insomnia, but for behavioral problems as well, in patients with autistic disorder. Hindawi Publishing Corporation 2014 2014-05-14 /pmc/articles/PMC4052092/ /pubmed/24955274 http://dx.doi.org/10.1155/2014/561071 Text en Copyright © 2014 Kentaro Kawabe et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kawabe, Kentaro
Horiuchi, Fumie
Oka, Yasunori
Ueno, Shu-ichi
The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
title The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
title_full The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
title_fullStr The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
title_full_unstemmed The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
title_short The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder
title_sort melatonin receptor agonist ramelteon effectively treats insomnia and behavioral symptoms in autistic disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052092/
https://www.ncbi.nlm.nih.gov/pubmed/24955274
http://dx.doi.org/10.1155/2014/561071
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