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Current and Emerging Biomarkers of Cell Death in Human Disease
Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and mole...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052120/ https://www.ncbi.nlm.nih.gov/pubmed/24949464 http://dx.doi.org/10.1155/2014/690103 |
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author | Li, Kongning Wu, Deng Chen, Xi Zhang, Ting Zhang, Lu Yi, Ying Miao, Zhengqiang Jin, Nana Bi, Xiaoman Wang, Hongwei Xu, Jianzhen Wang, Dong |
author_facet | Li, Kongning Wu, Deng Chen, Xi Zhang, Ting Zhang, Lu Yi, Ying Miao, Zhengqiang Jin, Nana Bi, Xiaoman Wang, Hongwei Xu, Jianzhen Wang, Dong |
author_sort | Li, Kongning |
collection | PubMed |
description | Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases. |
format | Online Article Text |
id | pubmed-4052120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40521202014-06-19 Current and Emerging Biomarkers of Cell Death in Human Disease Li, Kongning Wu, Deng Chen, Xi Zhang, Ting Zhang, Lu Yi, Ying Miao, Zhengqiang Jin, Nana Bi, Xiaoman Wang, Hongwei Xu, Jianzhen Wang, Dong Biomed Res Int Review Article Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases. Hindawi Publishing Corporation 2014 2014-05-18 /pmc/articles/PMC4052120/ /pubmed/24949464 http://dx.doi.org/10.1155/2014/690103 Text en Copyright © 2014 Kongning Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Kongning Wu, Deng Chen, Xi Zhang, Ting Zhang, Lu Yi, Ying Miao, Zhengqiang Jin, Nana Bi, Xiaoman Wang, Hongwei Xu, Jianzhen Wang, Dong Current and Emerging Biomarkers of Cell Death in Human Disease |
title | Current and Emerging Biomarkers of Cell Death in Human Disease |
title_full | Current and Emerging Biomarkers of Cell Death in Human Disease |
title_fullStr | Current and Emerging Biomarkers of Cell Death in Human Disease |
title_full_unstemmed | Current and Emerging Biomarkers of Cell Death in Human Disease |
title_short | Current and Emerging Biomarkers of Cell Death in Human Disease |
title_sort | current and emerging biomarkers of cell death in human disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052120/ https://www.ncbi.nlm.nih.gov/pubmed/24949464 http://dx.doi.org/10.1155/2014/690103 |
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