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Current and Emerging Biomarkers of Cell Death in Human Disease

Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and mole...

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Autores principales: Li, Kongning, Wu, Deng, Chen, Xi, Zhang, Ting, Zhang, Lu, Yi, Ying, Miao, Zhengqiang, Jin, Nana, Bi, Xiaoman, Wang, Hongwei, Xu, Jianzhen, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052120/
https://www.ncbi.nlm.nih.gov/pubmed/24949464
http://dx.doi.org/10.1155/2014/690103
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author Li, Kongning
Wu, Deng
Chen, Xi
Zhang, Ting
Zhang, Lu
Yi, Ying
Miao, Zhengqiang
Jin, Nana
Bi, Xiaoman
Wang, Hongwei
Xu, Jianzhen
Wang, Dong
author_facet Li, Kongning
Wu, Deng
Chen, Xi
Zhang, Ting
Zhang, Lu
Yi, Ying
Miao, Zhengqiang
Jin, Nana
Bi, Xiaoman
Wang, Hongwei
Xu, Jianzhen
Wang, Dong
author_sort Li, Kongning
collection PubMed
description Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases.
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spelling pubmed-40521202014-06-19 Current and Emerging Biomarkers of Cell Death in Human Disease Li, Kongning Wu, Deng Chen, Xi Zhang, Ting Zhang, Lu Yi, Ying Miao, Zhengqiang Jin, Nana Bi, Xiaoman Wang, Hongwei Xu, Jianzhen Wang, Dong Biomed Res Int Review Article Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases. Hindawi Publishing Corporation 2014 2014-05-18 /pmc/articles/PMC4052120/ /pubmed/24949464 http://dx.doi.org/10.1155/2014/690103 Text en Copyright © 2014 Kongning Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Kongning
Wu, Deng
Chen, Xi
Zhang, Ting
Zhang, Lu
Yi, Ying
Miao, Zhengqiang
Jin, Nana
Bi, Xiaoman
Wang, Hongwei
Xu, Jianzhen
Wang, Dong
Current and Emerging Biomarkers of Cell Death in Human Disease
title Current and Emerging Biomarkers of Cell Death in Human Disease
title_full Current and Emerging Biomarkers of Cell Death in Human Disease
title_fullStr Current and Emerging Biomarkers of Cell Death in Human Disease
title_full_unstemmed Current and Emerging Biomarkers of Cell Death in Human Disease
title_short Current and Emerging Biomarkers of Cell Death in Human Disease
title_sort current and emerging biomarkers of cell death in human disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052120/
https://www.ncbi.nlm.nih.gov/pubmed/24949464
http://dx.doi.org/10.1155/2014/690103
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