Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies

Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directe...

Descripción completa

Detalles Bibliográficos
Autores principales: Farini, Andrea, Sitzia, Clementina, Erratico, Silvia, Meregalli, Mirella, Torrente, Yvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052166/
https://www.ncbi.nlm.nih.gov/pubmed/24959590
http://dx.doi.org/10.1155/2014/818107
_version_ 1782320200440348672
author Farini, Andrea
Sitzia, Clementina
Erratico, Silvia
Meregalli, Mirella
Torrente, Yvan
author_facet Farini, Andrea
Sitzia, Clementina
Erratico, Silvia
Meregalli, Mirella
Torrente, Yvan
author_sort Farini, Andrea
collection PubMed
description Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing the dystrophic muscle damage using gene transfer or cell therapy. Here we discussed current knowledge about involvement of immune system responses to experimental therapies in MDs.
format Online
Article
Text
id pubmed-4052166
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40521662014-06-23 Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies Farini, Andrea Sitzia, Clementina Erratico, Silvia Meregalli, Mirella Torrente, Yvan Biomed Res Int Review Article Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing the dystrophic muscle damage using gene transfer or cell therapy. Here we discussed current knowledge about involvement of immune system responses to experimental therapies in MDs. Hindawi Publishing Corporation 2014 2014-05-19 /pmc/articles/PMC4052166/ /pubmed/24959590 http://dx.doi.org/10.1155/2014/818107 Text en Copyright © 2014 Andrea Farini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Farini, Andrea
Sitzia, Clementina
Erratico, Silvia
Meregalli, Mirella
Torrente, Yvan
Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
title Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
title_full Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
title_fullStr Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
title_full_unstemmed Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
title_short Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies
title_sort influence of immune responses in gene/stem cell therapies for muscular dystrophies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052166/
https://www.ncbi.nlm.nih.gov/pubmed/24959590
http://dx.doi.org/10.1155/2014/818107
work_keys_str_mv AT fariniandrea influenceofimmuneresponsesingenestemcelltherapiesformusculardystrophies
AT sitziaclementina influenceofimmuneresponsesingenestemcelltherapiesformusculardystrophies
AT erraticosilvia influenceofimmuneresponsesingenestemcelltherapiesformusculardystrophies
AT meregallimirella influenceofimmuneresponsesingenestemcelltherapiesformusculardystrophies
AT torrenteyvan influenceofimmuneresponsesingenestemcelltherapiesformusculardystrophies

Ejemplares similares