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Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate
Belatacept has been found to be efficient at preserving good kidney function in maintenance kidney-transplant patients. Herein, we report on the use of belatacept as a rescue therapy for two kidney-transplant patients presenting with severe adverse events after treatment with calcineurin inhibitors...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052196/ https://www.ncbi.nlm.nih.gov/pubmed/24963437 http://dx.doi.org/10.1155/2014/190516 |
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author | Belliere, Julie Guilbeau-Frugier, Céline Del Bello, Arnaud Esposito, Laure Capuani, Caroline Cardeau-Desangles, Isabelle Rostaing, Lionel Kamar, Nassim |
author_facet | Belliere, Julie Guilbeau-Frugier, Céline Del Bello, Arnaud Esposito, Laure Capuani, Caroline Cardeau-Desangles, Isabelle Rostaing, Lionel Kamar, Nassim |
author_sort | Belliere, Julie |
collection | PubMed |
description | Belatacept has been found to be efficient at preserving good kidney function in maintenance kidney-transplant patients. Herein, we report on the use of belatacept as a rescue therapy for two kidney-transplant patients presenting with severe adverse events after treatment with calcineurin inhibitors (CNIs) and mammalian target-of-rapamycin (mTOR) inhibitors. Two kidney-transplant patients developed severely impaired kidney function after receiving CNIs. The use of everolimus was associated with severe angioedema. Belatacept was then successfully used to improve kidney function in both cases, even though estimated glomerular-filtration rate before conversion was <20 mL/min. These case reports show that belatacept can be used as a rescue therapy, even if kidney function is very low in kidney-transplant patients who cannot tolerate CNIs and/or mTOR inhibitors. |
format | Online Article Text |
id | pubmed-4052196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40521962014-06-24 Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate Belliere, Julie Guilbeau-Frugier, Céline Del Bello, Arnaud Esposito, Laure Capuani, Caroline Cardeau-Desangles, Isabelle Rostaing, Lionel Kamar, Nassim Case Rep Transplant Case Report Belatacept has been found to be efficient at preserving good kidney function in maintenance kidney-transplant patients. Herein, we report on the use of belatacept as a rescue therapy for two kidney-transplant patients presenting with severe adverse events after treatment with calcineurin inhibitors (CNIs) and mammalian target-of-rapamycin (mTOR) inhibitors. Two kidney-transplant patients developed severely impaired kidney function after receiving CNIs. The use of everolimus was associated with severe angioedema. Belatacept was then successfully used to improve kidney function in both cases, even though estimated glomerular-filtration rate before conversion was <20 mL/min. These case reports show that belatacept can be used as a rescue therapy, even if kidney function is very low in kidney-transplant patients who cannot tolerate CNIs and/or mTOR inhibitors. Hindawi Publishing Corporation 2014 2014-05-18 /pmc/articles/PMC4052196/ /pubmed/24963437 http://dx.doi.org/10.1155/2014/190516 Text en Copyright © 2014 Julie Belliere et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Belliere, Julie Guilbeau-Frugier, Céline Del Bello, Arnaud Esposito, Laure Capuani, Caroline Cardeau-Desangles, Isabelle Rostaing, Lionel Kamar, Nassim Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate |
title | Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate |
title_full | Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate |
title_fullStr | Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate |
title_full_unstemmed | Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate |
title_short | Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate |
title_sort | beneficial effect of conversion to belatacept in kidney-transplant patients with a low glomerular-filtration rate |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052196/ https://www.ncbi.nlm.nih.gov/pubmed/24963437 http://dx.doi.org/10.1155/2014/190516 |
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