The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy

Objective. The aim of this study was to evaluate the effects of tonsillectomy as a treatment for IgA nephropathy in relation to renal pathological findings. Methods. This is a retrospective analysis of 13 patients having IgA nephropathy treated by tonsillectomy. Results. UP/UCre levels decreased fro...

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Autores principales: Nomura, Tsutomu, Makizumi, Yoshimi, Yoshida, Tsuyoshi, Yamasoba, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052205/
https://www.ncbi.nlm.nih.gov/pubmed/24959178
http://dx.doi.org/10.1155/2014/451612
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author Nomura, Tsutomu
Makizumi, Yoshimi
Yoshida, Tsuyoshi
Yamasoba, Tatsuya
author_facet Nomura, Tsutomu
Makizumi, Yoshimi
Yoshida, Tsuyoshi
Yamasoba, Tatsuya
author_sort Nomura, Tsutomu
collection PubMed
description Objective. The aim of this study was to evaluate the effects of tonsillectomy as a treatment for IgA nephropathy in relation to renal pathological findings. Methods. This is a retrospective analysis of 13 patients having IgA nephropathy treated by tonsillectomy. Results. UP/UCre levels decreased from 820.8 to 585.4 one month postsurgery and then showed slight worsening to 637.3 at the most recent follow-up. There was no significant difference in the improvement rate between pathological grades I–III and IV. There was positive correlation between Pre-UP/UCre level and the reduction rate of UP/UCre, which was statistically significant (R = 0.667, R (2) = 0.445, and P = 0.01). Conclusions. Reduction of UP/UCre at one month postsurgery is considered to be an overall prognostic factor, and tonsillectomy is considered to be an effective therapy for IgA patients regardless of the grade of renal pathology.
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spelling pubmed-40522052014-06-23 The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy Nomura, Tsutomu Makizumi, Yoshimi Yoshida, Tsuyoshi Yamasoba, Tatsuya Int J Otolaryngol Research Article Objective. The aim of this study was to evaluate the effects of tonsillectomy as a treatment for IgA nephropathy in relation to renal pathological findings. Methods. This is a retrospective analysis of 13 patients having IgA nephropathy treated by tonsillectomy. Results. UP/UCre levels decreased from 820.8 to 585.4 one month postsurgery and then showed slight worsening to 637.3 at the most recent follow-up. There was no significant difference in the improvement rate between pathological grades I–III and IV. There was positive correlation between Pre-UP/UCre level and the reduction rate of UP/UCre, which was statistically significant (R = 0.667, R (2) = 0.445, and P = 0.01). Conclusions. Reduction of UP/UCre at one month postsurgery is considered to be an overall prognostic factor, and tonsillectomy is considered to be an effective therapy for IgA patients regardless of the grade of renal pathology. Hindawi Publishing Corporation 2014 2014-05-19 /pmc/articles/PMC4052205/ /pubmed/24959178 http://dx.doi.org/10.1155/2014/451612 Text en Copyright © 2014 Tsutomu Nomura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nomura, Tsutomu
Makizumi, Yoshimi
Yoshida, Tsuyoshi
Yamasoba, Tatsuya
The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy
title The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy
title_full The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy
title_fullStr The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy
title_full_unstemmed The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy
title_short The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy
title_sort relationship between the efficacy of tonsillectomy and renal pathology in the patients with iga nephropathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052205/
https://www.ncbi.nlm.nih.gov/pubmed/24959178
http://dx.doi.org/10.1155/2014/451612
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