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Reporter Assay for Endo/Lysosomal Escape of Toxin-Based Therapeutics

Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic effect once they have escaped from the endosomes or lysosomes. In this study, the reporters—horseradish peroxidase (HRP), Alexa Fluor 488 ((Alexa)) and ricin A-chain (RTA)—were investigated for their capaci...

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Detalles Bibliográficos
Autores principales:	Gilabert-Oriol, Roger, Thakur, Mayank, von Mallinckrodt, Benedicta, Bhargava, Cheenu, Wiesner, Burkhard, Eichhorst, Jenny, Melzig, Matthias F., Fuchs, Hendrik, Weng, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052257/ https://www.ncbi.nlm.nih.gov/pubmed/24859158 http://dx.doi.org/10.3390/toxins6051644

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