Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta

New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limite...

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Autores principales: Huang, Tzu-Zin, Chen, Bo-Wei, Huang, Chiung-Yao, Hwang, Tsong-Long, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052299/
https://www.ncbi.nlm.nih.gov/pubmed/24796303
http://dx.doi.org/10.3390/md12052446
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author Huang, Tzu-Zin
Chen, Bo-Wei
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Huang, Tzu-Zin
Chen, Bo-Wei
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Huang, Tzu-Zin
collection PubMed
description New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1–7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
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spelling pubmed-40522992014-06-11 Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta Huang, Tzu-Zin Chen, Bo-Wei Huang, Chiung-Yao Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1–7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. MDPI 2014-04-30 /pmc/articles/PMC4052299/ /pubmed/24796303 http://dx.doi.org/10.3390/md12052446 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Tzu-Zin
Chen, Bo-Wei
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
title Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
title_full Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
title_fullStr Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
title_full_unstemmed Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
title_short Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
title_sort eunicellin-based diterpenoids, hirsutalins n–r, from the formosan soft coral cladiella hirsuta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052299/
https://www.ncbi.nlm.nih.gov/pubmed/24796303
http://dx.doi.org/10.3390/md12052446
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