Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.

Three new resveratrol derivatives, namely, resveratrodehydes A–C (1–3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory act...

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Autores principales: Wang, Jinhua, Cox, Daniel G., Ding, Weijia, Huang, Guanghao, Lin, Yongcheng, Li, Chunyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052320/
https://www.ncbi.nlm.nih.gov/pubmed/24828291
http://dx.doi.org/10.3390/md12052840
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author Wang, Jinhua
Cox, Daniel G.
Ding, Weijia
Huang, Guanghao
Lin, Yongcheng
Li, Chunyuan
author_facet Wang, Jinhua
Cox, Daniel G.
Ding, Weijia
Huang, Guanghao
Lin, Yongcheng
Li, Chunyuan
author_sort Wang, Jinhua
collection PubMed
description Three new resveratrol derivatives, namely, resveratrodehydes A–C (1–3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC(5)(0) < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC(50) < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay.
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spelling pubmed-40523202014-06-11 Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp. Wang, Jinhua Cox, Daniel G. Ding, Weijia Huang, Guanghao Lin, Yongcheng Li, Chunyuan Mar Drugs Article Three new resveratrol derivatives, namely, resveratrodehydes A–C (1–3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC(5)(0) < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC(50) < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay. MDPI 2014-05-13 /pmc/articles/PMC4052320/ /pubmed/24828291 http://dx.doi.org/10.3390/md12052840 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Jinhua
Cox, Daniel G.
Ding, Weijia
Huang, Guanghao
Lin, Yongcheng
Li, Chunyuan
Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
title Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
title_full Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
title_fullStr Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
title_full_unstemmed Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
title_short Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
title_sort three new resveratrol derivatives from the mangrove endophytic fungus alternaria sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052320/
https://www.ncbi.nlm.nih.gov/pubmed/24828291
http://dx.doi.org/10.3390/md12052840
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