Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle

Five new eunicellin-based diterpenoids, klymollins T–X (1–5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Fang-Yu, Hsu, Fang-Jung, Tai, Chi-Jen, Wei, Wen-Chi, Yang, Ning-Sun, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052331/
https://www.ncbi.nlm.nih.gov/pubmed/24857963
http://dx.doi.org/10.3390/md12053060
_version_ 1782320224856440832
author Chang, Fang-Yu
Hsu, Fang-Jung
Tai, Chi-Jen
Wei, Wen-Chi
Yang, Ning-Sun
Sheu, Jyh-Horng
author_facet Chang, Fang-Yu
Hsu, Fang-Jung
Tai, Chi-Jen
Wei, Wen-Chi
Yang, Ning-Sun
Sheu, Jyh-Horng
author_sort Chang, Fang-Yu
collection PubMed
description Five new eunicellin-based diterpenoids, klymollins T–X (1–5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.
format Online
Article
Text
id pubmed-4052331
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-40523312014-06-11 Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle Chang, Fang-Yu Hsu, Fang-Jung Tai, Chi-Jen Wei, Wen-Chi Yang, Ning-Sun Sheu, Jyh-Horng Mar Drugs Article Five new eunicellin-based diterpenoids, klymollins T–X (1–5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines. MDPI 2014-05-22 /pmc/articles/PMC4052331/ /pubmed/24857963 http://dx.doi.org/10.3390/md12053060 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chang, Fang-Yu
Hsu, Fang-Jung
Tai, Chi-Jen
Wei, Wen-Chi
Yang, Ning-Sun
Sheu, Jyh-Horng
Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
title Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
title_full Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
title_fullStr Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
title_full_unstemmed Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
title_short Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
title_sort klymollins t–x, bioactive eunicellin-based diterpenoids from the soft coral klyxum molle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052331/
https://www.ncbi.nlm.nih.gov/pubmed/24857963
http://dx.doi.org/10.3390/md12053060
work_keys_str_mv AT changfangyu klymollinstxbioactiveeunicellinbasedditerpenoidsfromthesoftcoralklyxummolle
AT hsufangjung klymollinstxbioactiveeunicellinbasedditerpenoidsfromthesoftcoralklyxummolle
AT taichijen klymollinstxbioactiveeunicellinbasedditerpenoidsfromthesoftcoralklyxummolle
AT weiwenchi klymollinstxbioactiveeunicellinbasedditerpenoidsfromthesoftcoralklyxummolle
AT yangningsun klymollinstxbioactiveeunicellinbasedditerpenoidsfromthesoftcoralklyxummolle
AT sheujyhhorng klymollinstxbioactiveeunicellinbasedditerpenoidsfromthesoftcoralklyxummolle

Ejemplares similares